A practical reference on mitochondrial biogenesis: what it is, how it behaves, what the literature reports, and where the honest uncertainties sit.
Reviewed 2025-09-17. Anything still debated is marked as such rather than presented as settled.
In rodent studies, SR9009 has been reported to increase mitochondrial content in skeletal muscle and improve exercise endurance under some conditions. These findings led to popular descriptions such as an exercise mimetic, although that term oversimplifies the biology. Effects vary by dose, timing, tissue, and model. The compound's influence on circadian pathways means that time of administration can matter in experiments. Whether similar metabolic changes occur in humans remains largely unexplored in controlled published trials.
Pharmacokinetic data for SR9009 are limited in published literature. Some reports indicate low oral bioavailability and rapid clearance in animals, which complicates interpretation of exposure and effect. Researchers often use injected routes in preclinical work to achieve measurable systemic levels. Analytical studies rely on mass spectrometry to detect the parent compound and its metabolites. Questions about tissue distribution, active metabolites, and long-term consequences remain open. Species differences in metabolism can affect observed half-life and target engagement.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. These receptors help regulate circadian rhythms and metabolic gene expression. In laboratory experiments, SR9009 binds these receptors and alters transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. It is not a naturally occurring compound and has no approved therapeutic use. Research interest stems from its ability to modify energy metabolism in cells and animal models.
Preclinical reports describe effects on exercise endurance, mitochondrial content, and lipid profiles in rodents, but these findings come from specific experimental conditions. Many studies use high doses or delivery methods that may not translate directly to human use. SR9009 has been reported to have low oral bioavailability and a short half-life, which complicates interpretation of oral dosing studies. It is not established as safe or effective for any indication. Literature discussions often separate its pharmacological mechanism from unverified claims made in fitness and supplement markets.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not an approved medicine and has no established human therapeutic use. The compound appears in scientific literature as a tool for probing circadian and metabolic regulation. Online sellers often label it as a research chemical, sometimes using the nickname Stenabolic. Its chemical identity is distinct from selective androgen receptor modulators, stimulants, and peroxisome proliferator-activated receptor delta agonists. Researchers use it mainly in cell and animal experiments.
| Property | Value | Notes |
|---|---|---|
| Chemical class | Synthetic small-molecule REV-ERB agonist | Not a hormone or natural product |
| Primary targets | REV-ERBα and REV-ERBβ | Nuclear receptors involved in circadian and metabolic regulation |
| Appearance | White to off-white solid | Typical for purified research samples |
| Solubility | Soluble in DMSO and ethanol; low water solubility | Laboratory solubility depends on solvent and purity |
| Common synonyms | SR9009; Stenabolic | Stenabolic is a colloquial name, not a formal chemical name |
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
Because REV-ERB receptors are core clock components, SR9009 has been examined for effects on daily rhythms as well as metabolism. Research has explored whether the compound can shift or reinforce circadian gene expression in tissues such as liver and muscle. Some studies report improved metabolic markers in obese or diabetic mice, while others show context-dependent responses. Questions remain about which effects are direct, which are secondary to timing, and how they might differ across species.
Laboratory samples of SR9009 are typically supplied as a white to off-white powder. The compound dissolves readily in organic solvents such as dimethyl sulfoxide and ethanol, while its solubility in water is low. Because of this solubility profile, researchers often prepare concentrated stock solutions in an organic solvent before diluting them into aqueous assay buffers. Light exposure, moisture, and repeated freeze-thaw cycles can degrade many small molecules, so handling procedures usually aim to minimize these factors. Purity is commonly checked before use.
Storage conditions for research-grade SR9009 generally involve a freezer at approximately minus twenty degrees Celsius, sometimes lower for long-term preservation. Containers should remain tightly closed and protected from light. Desiccants may be used to limit moisture uptake. Solutions are often stored in aliquots to avoid repeated warming and cooling. Stability data for the compound under various conditions are limited, so laboratories typically follow supplier recommendations and verify performance through periodic analytical checks rather than assuming indefinite stability.
Regulatory treatment of SR9009 reflects its investigational status. The compound has no approved human therapeutic indication, and sports authorities prohibit its use. It appears on anti-doping lists as a non-approved substance or metabolic modulator, depending on the list version. Products sold online as research chemicals are not quality-controlled medicines, so their identity and purity can differ from the label. Such products may also contain unlisted compounds, which complicates both testing and safety assessment.
Scientific discussion of SR9009 often separates animal evidence from human anecdote. Rodent studies provide controlled data on endurance, metabolism, and gene expression, but they use specific strains, doses, and treatment durations. Human reports are mostly uncontrolled and cannot establish cause and effect. Open questions include oral bioavailability, tissue distribution, metabolic stability, and long-term effects. Review articles generally call for more rigorous pharmacokinetic and safety research before any clinical use could be considered.
Analytical methods for SR9009 typically rely on liquid chromatography coupled with tandem mass spectrometry. The technique can separate the parent compound from related substances and detect low concentrations in biological matrices. Urine and blood are common samples in anti-doping testing, while in vitro studies may use cell culture media. Rapid metabolism and low expected concentrations make method validation important for reliable identification. Exact metabolite patterns can vary by species and are not fully mapped.
Analytical chemists detect SR9009 with liquid chromatography-tandem mass spectrometry, commonly abbreviated LC-MS/MS. Sample preparation may involve protein precipitation, liquid-liquid extraction, or solid-phase extraction before analysis. Laboratories can target the parent compound or its metabolites, depending on the matrix and the purpose of testing. Anti-doping methods require sensitive and specific assays because concentrations in biological samples can be low. Reference standards and validated methods are essential for reliable identification and quantification.
Regulatory agencies have not approved SR9009 for human therapeutic use. It is typically sold as a research chemical with labels stating that it is not for human consumption. The World Anti-Doping Agency prohibits the substance in sport, generally under the category of non-approved substances. Customs and national laws may restrict importation, sale, or possession. Product quality and legal status can vary by country and vendor, and therapeutic claims are not permitted in regulated advertising because the compound lacks approval.
Several misconceptions surround SR9009. It is often described as a SARM, a steroid, or an exercise pill, but its known target is the REV-ERB receptor family. Rodent studies have examined exercise capacity and metabolic markers, yet human outcomes remain unproven. Oral bioavailability appears low in animals, and human pharmacokinetics are not well characterized. Online products may contain impurities or different compounds, so identity and purity testing are important for research use.
The following day, Foreign Minister Sihasak Phuangketkeow was named as Bhumjaithai's second candidate for prime minister as a backup. On 25 December, Pheu Thai announced its list of 500 candidates to contest every House seat. Anutin ruled out any coalition between Bhumjaithai and parties seeking to amend Article 112 on lèse-majesté following statements by Natthaphong that the People's Party would never vote for Anutin to become prime minister again. On 26 December, the Democrat Party announced its three candidates for prime minister: party leader Abhisit Vejjajiva, Korn Chatikavanij, and Karndee Leopairote, at its headquarters in Bangkok. Palang Pracharath Party leader Prawit Wongsuwon announced his intention to retire from politics after withdrawing as one of the party's three prime ministerial candidates. His withdrawal as a prime ministerial candidate was joined by deputy party leader Thirachai Phuvanatnaranubala, who also announced his withdrawal from politics. On 28 December, representatives from 52 political parties registered their parties' lists of prime ministerial and party-list candidates.
== Personnel == Duncan Sheik – vocals, backing vocals, electric piano, harmonium, synthesizers, acoustic guitars, electric guitars Patrick Leonard – acoustic piano, electric piano, synthesizers, organs, Moog bass Gerry Leonard – electric guitars, mandolin, loops, ambiences, backing vocals (3) Jeff Allen – bass Doug Yowell – drums (1, 2, 4–11), percussion Additional musicians
== External links == Overview of all the structural information available in the PDB for UniProt: P09958 (Human Furin) at the PDBe-KB. Overview of all the structural information available in the PDB for UniProt: P23188 (Mouse Furin) at the PDBe-KB.
==== Increased blood pressure ==== In a study done by ML Maitland, a mean blood pressure increase of 8.2 mm Hg systolic and 6.5 mm Hg diastolic was reported in the first 24 hours after the first treatment with sorafenib, a VEGF pathway inhibitor.
== Coaching == In 1993, the Milwaukee Brewers named Epstein manager of the rookie league Helena Brewers, who played in the Pioneer League. He only managed 11 games, as his hitting philosophy learned under Ted Williams was contrary to the current trend at the time.
Sources: en.wikipedia.org
It thus seems likely that while δ-opioid agonists can produce respiratory depression at very high doses, at lower doses they have the opposite effect, a fact that may make mixed mu/delta agonists such as DPI-3290 potentially very useful drugs that might be much safer than the μ agonists currently used for pain relief. Many delta agonists may also cause seizures at high doses, although not all delta agonists produce this effect. Of additional interest is the potential for delta agonists to be developed for use as a novel class of antidepressant drugs, following robust evidence of both antidepressant effects and also upregulation of BDNF production in the brain in animal models of depression. These antidepressant effects have been linked to endogenous opioid peptides acting at δ- and μ-opioid receptors, and so can also be produced by enkephalinase inhibitors such as RB-101. However, in human models the data for antidepressant effects remains inconclusive. In the 2008 Phase 2 clinical trial by Astra Zeneca, NCT00759395, 15 patients were treated with the selective delta agonist AZD 2327. The results showed no significant effect on mood suggesting that δ-opioid receptor modulation might not participate in the regulation of mood in humans. However, doses were administered at low doses and the pharmacological data also remains inconclusive. Further trials are required. Another interesting aspect of δ-opioid receptor function is the suggestion of μ/δ-opioid receptor interactions. At the extremes of this suggestion lies the possibility of a μ/δ opioid receptor oligomer.
The council deals with a variety of local issues such as outdoor patio applications, neighbourhood traffic plans, and exemptions from certain by-laws such as retail signs, fences, trees and ravines. Decisions made by community council are approved by Toronto City Council in order to take effect.
Over the following decades, Article 370 was steadily diluted through presidential orders that extended various provisions of the Indian constitution to the state without full legislative consent, weakening its autonomy. This deepened political disillusionment, particularly in the Kashmir Valley. In 1965, through a Presidential Order, the Bakshi Ghulam Mohammad-led Congress government in Jammu and Kashmir amended the constitution to replace the titles of Prime Minister and Sadr-e-Riyasat with Chief Minister and Governor, aligning them with other Indian states. Abdullah was released in 1968 and, following the Indira–Sheikh Accord of 1975, returned to power as chief minister after a political reconciliation with the central government. After his death in 1982, unrest and violence persisted in the Kashmiri Valley and, following a disputed state election in 1987, an insurgency persisted in protest over autonomy and rights. In the early 1990s, amid the rise of militancy and targeted violence, a mass exodus of Kashmiri Hindus occurred from the Kashmir Valley. Through the 1990s and 2000s, the region witnessed prolonged violence between insurgent groups and Indian security forces. While Article 370 had come to be seen as effectively permanent, it historically faced ideological opposition. In the 1950s, Syama Prasad Mookerjee, founder of the Bharatiya Jana Sangh (BJS), opposed Article 370 on grounds that it hindered national integration and created unequal constitutional treatment.
== History == In 1849, the French chemists Jean-François Persoz and Bloch, and the German chemist Peter Kremers (1827–?), independently first synthesized thionyl chloride by reacting phosphorus pentachloride with sulfur dioxide. However, their products were impure: both Persoz and Kremers claimed that thionyl chloride contained phosphorus, and Kremers recorded its boiling point as 100 °C (instead of 74.6 °C). In 1857, the German-Italian chemist Hugo Schiff subjected crude thionyl chloride to repeated fractional distillations and obtained a liquid which boiled at 82 °C and which he called Thionylchlorid. In 1859, the German chemist Georg Ludwig Carius noted that thionyl chloride could be used to make acid anhydrides and acyl chlorides from carboxylic acids and to make alkyl chlorides from alcohols.
Sources: en.wikipedia.org
==== Foreign policy ==== On June 12, 2017, U.S. senators agreed to legislation imposing new sanctions on Russia and Iran. The bill was opposed only by Sanders and Republican Rand Paul. He supported the sanctions on Russia, but voted against the bill because he believed the sanctions could endanger the Iran nuclear deal. In 2018, Sanders sponsored a bill and was joined by senators Chris Murphy (D–CT) and Mike Lee (R–UT) to invoke the 1973 War Powers Resolution to end US support for the Saudi-led military intervention in Yemen, which has resulted in hundreds of thousands of civilian casualties and "millions more suffering from starvation and disease". After the assassination of Jamal Khashoggi in October 2018 (which was ordered by Saudi Arabian crown prince Mohammad bin Salman, according to multiple intelligence agencies), his bill attracted bipartisan co-sponsors and support, and the Senate passed it by a vote of 56–41. The bill passed the House in February 2019 by a 247–175 vote and President Trump vetoed it in March, saying: "This resolution is an unnecessary, dangerous attempt to weaken my constitutional authorities, endangering the lives of American citizens and brave service members, both today and in the future." During the Gaza war, Sanders introduced several Joint Resolutions of Disapproval to block arms to Israel. All failed, but some Democrats voted for them. In November 2024, one such resolution garnered support from 18 senators. In April 2025, 15 senators supported another. In July 2025, 27 senators supported a resolution, a majority of Senate Democrats.
The 12th congressional district shifted significantly in the 2020 United States redistricting cycle following the 2020 census: while it kept Dearborn, it lost Ann Arbor while gaining parts of Detroit. While prior to redistricting, Dingell lived in Dearborn, she chose to move to Ann Arbor and run in the new 6th district, which was drawn to contain Washtenaw County and Detroit suburbs in western Wayne County. This allowed Rashida Tlaib, who represented the old 13th district, to run in the new 12th district. Dingell faced no opposition in the Democratic primary. In the general election, she defeated Republican Whittney Williams with 65.9% of the vote.
== Employee relations and opportunities == In February 2019, employees of three Ohio locations resigned en masse due to management changes, as well as what they alleged was a 50% reduction of the employee hourly pay rate, a claim denied by Sonic. In 2020, Sonic added a tipping feature via the online ordering app. In 2021, Sonic added an option to tip at the stalls.
Sources: en.wikipedia.org
It is a synthetic research compound that activates REV-ERB nuclear receptors. It is not an approved drug or dietary supplement. Most information comes from cell and animal studies.
It binds REV-ERBα and REV-ERBβ and changes transcription of metabolic genes. This can affect circadian rhythm, lipid use, and mitochondrial function. The full downstream effects are still under study.
No. Some rodent studies show increased endurance, but controlled human trials are lacking. Claims about human performance are not established by published evidence.
SR9009 is a synthetic REV-ERB agonist used in laboratory research. It is not an approved drug, and its effects in humans are not well characterized. It is often sold as a research chemical under the name Stenabolic.